Corporation announced today that it is a Grand
Challenges Explorations winner, an initiative funded by the Bill
& Melinda Gates Foundation. Dawn Smith, PhD., Temptime Executive
Director, New Product Development, will pursue an innovative global
health and development research project, titled "Low-Cost Vaccine Vial
Unit-Level Temperature Indicators that Display Cumulative and Peak
Exposures to Heat".
"As recommended by the World Health Organization (WHO), Vaccine Vial
Monitors (VVMs) currently used on vaccines distributed through United
Nations procurement agencies such as UNICEF, and other organizations and
governments, alert health care professionals in the field when vaccines
may have been exposed to damaging heat to avoid administration of
temperature-damaged vaccine to patients," explains Dr. Smith. She
continued, "The novel aspect of this application will be the integration
of the peak temperature indicator with the cumulative heat indicator,
providing a unique, simple and clear signal to the field worker so they
can decide if they should use the vaccine or not."
Grand Challenges Explorations (GCE) funds individuals worldwide who are
taking innovative approaches to some of the world's toughest and
persistent global health and development challenges. GCE invests in the
early stages of bold ideas that have real potential to solve the
problems people in th developing world face every day. Smith's project
is one of over 80 Grand Challenges Explorations Round 9 grants announced
today by the Bill & Melinda Gates Foundation.
"Investments in innovative global health research are already paying
off," said Chris Wilson, director of Global Health Discovery and
Translational Sciences at the Bill & Melinda Gates Foundation. "We
continue to be impressed by the novelty and innovative spirit of Grand
Challenges Explorations projects and are enthusiastic about this
exciting research. These investments hold real potential to yield new
solutions to improve the health of millions of people in the developing
world, and ensure that everyone has the chance to live a healthy
To receive funding, Dawn Smith and other Grand Challenges Explorations
Round 9 winners demonstrated in a two-page online application a creative
idea in one of five critical global heath and development topic areas
that included agriculture development, immunization and communications.
As principle investigator for the Grand Challenge Exploration, Dr. Smith
proposed the concept to develop low-cost individual vaccine vial
temperature indicators that provide a unique signal after a defined
cumulative heat exposure consistent with WHO PQS specifications for
Vaccine Vial Monitors AND to also provide an indication of brief
exposure to high temperatures that could cause vaccines to lose potency
and be rendered ineffective. The new dual function heat indicators will
be integrated in a single device that has a single visual signal
consistent with current VVMs - a square, white reactive surface in the
center of a circular reference surface that darkens with exposure to
"For more than 20 years, Temptime Corporation has worked with WHO, PATH,
and other organizations to develop technology to contribute to the
success of global immunization programs that have made such a tremendous
impact on saving the lives of people in developing nations," said Ted
Prusik, PhD, Temptime Senior Vice President and Director Life Sciences
and one of the inventors of the original Vaccine Vial Monitor. He
continued, "Temptime is very proud to receive a Grand Challenges
Explorations grant and we are fully dedicated to continue our support of
global immunization initiatives."
About Grand Challenges Explorations
Challenges Explorations is a US$100 million initiative funded by the Bill
& Melinda Gates Foundation. Launched in 2008, over 700 people in
45 countries have received Grand Challenges Explorations grants. The
grant program is open to anyone from any discipline and from any
organization. The initiative uses an agile, accelerated grant-making
process with short two-page online applications and no preliminary data
required. Initial grants of US$100,000 are awarded two times a year.
Successful projects have the opportunity to receive a follow-on grant of
up to US$1 million.
About Temptime Corporation
Temptime, the world leader in time-temperature indicators, plays a vital
role in the improvement of global health by providing solutions that
monitor temperature sensitive medical products, live tissue and devices.
Temptime uses its patented technologies to develop and produce devices
that provide definitive, irreversible readings while avoiding the
environmental hazards associated with battery operated devices. To learn
more about Temptime Corporation and its products, please visit www.temptimecorp.com.
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