Oxford Nanopore Technologies Ltd. today presented for the first time DNA
sequence data using its novel nanopore 'strand sequencing' technique and
proprietary high performance electronic devices GridION and MinION.
These data were presented by Clive G Brown, Chief Technology Officer,
who outlined the Company's pathway to a commercial product with highly
disruptive features including ultra long read lengths, high throughput
on electronic systems and real-time sequencing results. Oxford Nanopore
intends to commercialise GridION and MinION directly to customers within
Oxford Nanopore's GridION system consists of scalable instruments
(nodes) used with consumable cartridges that contain proprietary array
chips for multi-nanopore sensing. Each GridION node and cartridge is
initially designed to deliver tens of Gb of sequence data per 24 hour
period, with the user choosing whether to run for minutes or days
according to the experiment.
Oxford Nanopore will introduce a new model of versatile pricing schemes
designed to deliver a price per base that is as competitive as other
leading systems at launch. Further substantial pricing improvements are
expected with future development to the technology, in particular with
increases in nanopore processing speed and higher density electronic
Oxford Nanopore has also miniaturised these devices to develop the
MinION; a disposable DNA sequencing device the size of a USB memory
stick whose low cost, portability and ease of use are designed to make
DNA sequencing universally accessible. A single MinION is expected to
retail at less than $900.
"The exquisite science behind nanopore sensing has taken nearly two
decades to reach this point; a truly disruptive single molecule analysis
technique, designed alongside new electronics to be a universal
sequencing system. GridION and MinION are poised to deliver a
completely new range of benefits to researchers and clinicians,"
said Dr Gordon Sanghera, CEO of Oxford Nanopore. "Oxford Nanopore is
as much an electronics company as a biotechnology company, and the
development of a high-throughput electronics platform has been essential
for us to design and screen a large number of new candidate nanopores
and enzymes. Our toolbox is customer-ready and we will continue to
develop improved nanopore devices over many years, including ongoing
work in solid state devices."
Summary of presentation
At the Advances in Genome Biology and Technology conference (AGBT), FL,
US, Oxford Nanopore presented:
Notes to editors
Oxford Nanopore Technologies Ltd is developing a novel technology for
direct, electronic detection and analysis of single molecules using
nanopores. The modular, scalable GridION technology platform is designed
to offer substantial benefits in a variety of applications. The
miniaturised MinION device is the size of a USB memory stick, designed
for portable analysis of single molecules. Oxford Nanopore intends to
commercialise GridION and MinION directly to customers for DNA 'strand
sequencing' in 2012.
In addition to DNA sequencing, the system is also compatible with the
direct analysis of RNA. Oxford Nanopore is also developing a Protein
Analysis technology that combines target proteins with ligands for
direct, electronic analysis using protein nanopores. These nanopore
sensing techniques are combined with the Company's proprietary array
chip within the GridION system and MinION.
The Company is also developing the subsequent generation of nanopore
sensing devices based on solid-state nanopores.
Oxford Nanopore has licensed or owns more than 300 patents and patent
applications that relate to many aspects of nanopore sensing including
fundamental nanopore sensing patents, analysis using protein nanopores
or solid state nanopores and for the analysis of DNA, proteins and other
molecules, including the analysis of probe molecules on DNA. The Company
has collaborations and exclusive licensing deals with leading
institutions including the University of Oxford, Harvard and UCSC.
Oxford Nanopore has funding programmes in these laboratories to support
the science of nanopore sensing. This includes the use of functionalised
solid-state nanopores for molecular characterisation, methods of
fabricating solid-state nanopores and modifications of solid-state
nanopores to adjust sensitivity or other parameters.
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